高通量表面等离子体共振分析仪
仪器介绍
一种高通量、高灵敏度的表面等离子体共振（SPR）系统，能够对小分子和生物治疗药物进行有效的筛选、表征、工艺优化和质量控制。
参数
| Analysis temperature | 4°C to 40°C (maximum 20°C below ambient temperature) |
| Analysis time per cycle | Typically 2 to 15 min |
| Application | Kinetic characterization, kinetic screening single concentration, 2D kinetics of unknown, Clean screen, Binding level screen, Affinity screen, affinity characterization |
| Association rate constant (ka) | Proteins: up to 109 M-1s-1 |
| Automation | 60 h unattended operation |
| Baseline drift | Typically < 0.3 RU/min |
| Baseline noise | Typically < 0.02 RU (RMS) |
| Capacity | 4 × 96- or 384-well microplates, normal and deep-well |
| Dissociation rate constant (kd) | 10-6 to 0.5 s-1 |
| Flow cell volume | 40 nL |
| Flow rate | 1 to 100 μL/min |
| Injection volume | 1 to 200 μL |
| Molecular weight detection | No lower limit for organic molecules |
| Number of flow cells | 16 in 8 channels |
| Sample concentration min | ≥ 1 picomolar (pM) |
| Sample type | Small-molecule drug candidates to high-molecular weight proteins (also DNA, RNA, polysaccharides, lipids, cells, and viruses) in various sample environments (e.g., in DMSO-containing buffers, plasma, and serum) |
| Sample volume min | Injection volume plus 20 to 50 μL (application dependent) |